J.C. Whisstock: search on Z-Library

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1

Perforin and granzymes: function, dysfunction and human pathology

Voskoboinik, Ilia, Whisstock, James C., Trapani, Joseph A.

Journal:

Nature Reviews Immunology

Year:

2015

Language:

english

File:

PDF, 787 KB

english, 2015

2

Brentuximab vedotin in T-cell lymphoma

van der Weyden, Carrie, Dickinson, Michael, Whisstock, James, Prince, H. Miles

Journal:

Expert Review of Hematology

Year:

2018

Language:

english

File:

PDF, 1.32 MB

english, 2018

3

Brinp1−/−mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, Susan R., Featherby, Travis J., Qu, Zhengdong, Giousoh, Aminah, Borg, Natalie A., Heng, Julian I., Whisstock, James C., Bird, Phillip I.

Journal:

Molecular Autism

Year:

2016

Language:

english

File:

PDF, 3.05 MB

english, 2016

4

Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes

Janet M Davies, Marita Scealy, YePing Cai, James Whisstock, Ian R Mackay, Merrill J Rowley

Journal:

Molecular Immunology

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

5

Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signalling Pathway in Drosophila

Henstridge, Michelle A., Aulsebrook, Lucinda, Koyama, Takashi, Johnson, Travis K., Whisstock, James C., Tiganis, Tony, Mirth, Christen K., Warr, Coral G.

Journal:

Year:

2018

Language:

english

File:

PDF, 3.02 MB

english, 2018

6

Protein structural alignments and functional genomics

James A. Irving, James C. Whisstock, Arthur M. Lesk

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2001

Language:

english

File:

PDF, 190 KB

english, 2001

7

Prediction of protein function from protein sequence and structure

Whisstock, James C., Lesk, Arthur M.

Journal:

Quarterly Reviews of Biophysics

Year:

2003

Language:

english

File:

PDF, 648 KB

english, 2003

8

New insights into the structure and function of the plasminogen/plasmin system

Law, Ruby HP, Abu-Ssaydeh, Diana, Whisstock, James C

Journal:

Current Opinion in Structural Biology

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

9

Reply to Klemba: Intracellular processing of the membrane-bound PfA-M1 neutral aminopeptidase, a target for new antimalarials

Whisstock, J. C., McGowan, S., Trenholme, K. R., Gardiner, D. L., Dalton, J. P.

Journal:

Proceedings of the National Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 69 KB

english, 2009

10

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Harbut, M. B., Velmourougane, G., Dalal, S., Reiss, G., Whisstock, J. C., Onder, O., Brisson, D., McGowan, S., Klemba, M., Greenbaum, D. C.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

11

RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly

Lo, Jennifer C. Y., Jamsai, Duangporn, O'Connor, Anne E., Borg, Claire, Clark, Brett J., Whisstock, James C., Field, Mark C., Adams, Vicki, Ishikawa, Tomomoto, Aitken, R. John, Whittle, Belinda, Goodn

Journal:

Year:

2012

Language:

english

File:

PDF, 1.94 MB

english, 2012

12

RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins

Faux, N. G., Huttley, G. A., Mahmood, K., Webb, G. I., Garcia de la Banda, M., Whisstock, J. C.

Journal:

Genome Research

Year:

2007

Language:

english

File:

PDF, 724 KB

english, 2007

13

Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway

Johns, Alex R., Henstridge, Michelle A., Saligari, Melissa J., Moore, Karyn A., Whisstock, James C., Warr, Coral G., Johnson, Travis K.

Journal:

G3 Genes|Genome|Genetics

Year:

2018

Language:

english

File:

PDF, 1.84 MB

english, 2018

14

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, Joakim E., Wu, Guojie, Mahatmanto, Tunjung, Durek, Thomas, Caradoc-Davies, Tom, Whisstock, James C., Law, Ruby, Craik, David J

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 892 KB

english, 2018

15

Use of synthetic peptides to delineate discontinuous sequence regions involved in epitope sites of the thyrotropin β-subunit

Peter T. Gomme, Philip E. Thompson, James Whisstock, Peter G. Stanton, Milton T. W. Hearn

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1999

Language:

english

File:

PDF, 722 KB

english, 1999

16

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Tina S. Skinner-Adams, Colin M. Stack, Katharine R. Trenholme, Chris L. Brown, Jolanta Grembecka, Jonathan Lowther, Artur Mucha, Marcin Drag, Pawel Kafarski, Sheena McGowan, James C. Whisstock, Donald

Journal:

Trends in Biochemical Sciences

Year:

2010

Language:

english

File:

PDF, 824 KB

english, 2010

17

Conservation within the myosin motor domain: implications for structure and function

M Jamie TV Cope, James Whisstock, Ivan Rayment, John Kendrick-Jones

Journal:

Year:

1996

Language:

english

File:

PDF, 3.10 MB

english, 1996

18

Conformational changes in serpins: I. the native and cleaved conformations of α1-antitrypsin

James C Whisstock, Richard Skinner, Robin W Carrell, Arthur M Lesk

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 1.27 MB

english, 2000

19

Structure of a Serpin-Enzyme Complex Probed by Cysteine Substitutions and Fluorescence Spectroscopy

Ludeman, Justin P., Whisstock, James C., Hopkins, Paul C.R., Le Bonniec, Bernard F., Bottomley, Stephen P.

Journal:

Biophysical Journal

Year:

2001

Language:

english

File:

PDF, 363 KB

english, 2001

20

High resolution structure of cleaved Serpin 42

Ellisdon, Andrew M, Zhang, Qingwei, Henstridge, Michelle A, Johnson, Travis K, Warr, Coral G, Law, Ruby HP, Whisstock, James C

Journal:

BMC Structural Biology

Year:

2014

Language:

english

File:

PDF, 904 KB

english, 2014

21

X-ray crystal structure of the streptococcal specific phage lysin PlyC

McGowan, S., Buckle, A. M., Mitchell, M. S., Hoopes, J. T., Gallagher, D. T., Heselpoth, R. D., Shen, Y., Reboul, C. F., Law, R. H. P., Fischetti, V. A., Whisstock, J. C., Nelson, D. C.

Journal:

Proceedings of the National Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

22

1-Antitrypsin Mmalton (Phe52-deleted) Forms Loop-Sheet Polymers in Vivo.: EVIDENCE FOR THE C SHEET MECHANISM OF POLYMERIZATION

Lomas, D. A., Elliott, P. R., Sidhar, S. K., Foreman, R. C., Finch, J. T., Cox, D. W., Whisstock, J. C., Carrell, R. W.

Journal:

Journal of Biological Chemistry

Year:

1995

File:

PDF, 13.59 MB

1995

23

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

Yamasaki, Masayuki, Sendall, Timothy J, Pearce, Mary C, Whisstock, James C, Huntington, James A

Journal:

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

24

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, Paul J., Law, Ruby H.P., Caradoc-Davies, Tom T., Whisstock, James C.

Journal:

Year:

2017

Language:

english

File:

PDF, 4.46 MB

english, 2017

25

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech

Pang, Siew Siew, Wijeyewickrema, Lakshmi C., Hor, Lilian, Tan, Sheareen, Lameignere, Emilie, Conway, Edward M., Blom, Anna M., Mohlin, Frida C., Liu, Xuyu, Payne, Richard J., Whisstock, James C., Pike

Journal:

The Journal of Immunology

Year:

2017

Language:

english

File:

PDF, 1.78 MB

english, 2017

26

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

Katherine Baran, Michelle Dunstone, Jenny Chia, Annette Ciccone, Kylie A. Browne, Christopher J.P. Clarke, Natalya Lukoyanova, Helen Saibil, James C. Whisstock, Ilia Voskoboinik, Joseph A. Trapani

Journal:

Year:

2009

Language:

english

File:

PDF, 1.38 MB

english, 2009

27

The Evolution of Enzyme Specificity inFasciola spp.

JamesA. Irving, TerryW. Spithill, RobertN. Pike, JamesC. Whisstock, PeterM. Smooker

Journal:

Journal of Molecular Evolution

Year:

2003

Language:

english

File:

PDF, 611 KB

english, 2003

28

The MACPF/CDC family of pore-forming toxins

Carlos J. Rosado, Stephanie Kondos, Tara E. Bull, Michael J. Kuiper, Ruby H. P. Law, Ashley M. Buckle, Ilia Voskoboinik, Phillip I. Bird, Joseph A. Trapani, James C. Whisstock, Michelle A. Dunstone

Journal:

Cellular Microbiology

Year:

2008

Language:

english

File:

PDF, 367 KB

english, 2008

29

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss withinEuteleostomi

Michael E D’Angelo, Michelle A Dunstone, James C Whisstock, Joseph A Trapani, Phillip I Bird

Journal:

BMC Evolutionary Biology

Year:

2012

Language:

english

File:

PDF, 903 KB

english, 2012

30

Mechanisms of serpin dysfunction in disease

Kaiserman, Dion, Whisstock, James C., Bird, Phillip I.

Journal:

Expert Reviews in Molecular Medicine

Year:

2006

Language:

english

File:

PDF, 2.43 MB

english, 2006

31

The Three-dimensional Structure of the Extracellular Adhesion Domain of the Sialic Acid-binding Adhesin SabA from Helicobacter pylori

Pang, Siew Siew, Nguyen, Stanley Thai Son, Perry, Andrew J., Day, Christopher J., Panjikar, Santosh, Tiralongo, Joe, Whisstock, James C., Kwok, Terry

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 3.25 MB

english, 2014

32

Importance of the Prime Subsites of the C1s Protease of the Classical Complement Pathway for Recognition of Substrates †

O'Brien, Grace, Quinsey, Noelene S., Whisstock, James C., Pike, Robert N.

Journal:

Year:

2003

Language:

english

File:

PDF, 72 KB

english, 2003

33

Maspin (SERPINB5) Is an Obligate Intracellular Serpin

Teoh, S. S. Y., Whisstock, J. C., Bird, P. I.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 5.44 MB

english, 2010

34

Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like

Henstridge, Michelle A., Johnson, Travis K., Warr, Coral G., Whisstock, James C.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 2.93 MB

english, 2014

35

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, Bradley A., Law, Ruby H. P., Caradoc-Davies, Tom T., Ekkel, Sue M., Bayly-Jones, Charles, Pang, Siew-Siew, Conroy, Paul J., Ramm, Georg, Radjainia, Mazdak, Venugopal, Hariprasad, Whisstock, Ja

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.42 MB

english, 2018

36

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Jamie A. Lopez, Amelia J. Brennan, James C. Whisstock, Ilia Voskoboinik, Joseph A. Trapani

Journal:

Trends in Immunology

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

37

The zymogen form of the catalytic region of the complement protease, C1s, is stabilized into a form unable to interact with substrates and cofactors

Robert N. Pike, Andrew J. Perry, Pascal G. Wilmann, Renee C. Duncan, James A. Huntington, James C. Whisstock, Lakshmi C. Wijeyewickrema

Journal:

Year:

2012

Language:

english

File:

PDF, 87 KB

english, 2012

38

Conformational Epitopes on the Diabetes Autoantigen GAD65 Identified by Peptide Phage Display and Molecular Modeling

Myers, M. A., Davies, J. M., Tong, J. C., Whisstock, J., Scealy, M., Mackay, I. R., Rowley, M. J.

Journal:

The Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 2.53 MB

english, 2000

39

The major human and mouse granzymes are structurally and functionally divergent

Kaiserman, D., Bird, C. H., Sun, J., Matthews, A., Ung, K., Whisstock, J. C., Thompson, P. E., Trapani, J. A., Bird, P. I.

Journal:

The Journal of Cell Biology

Year:

2006

Language:

english

File:

PDF, 1.64 MB

english, 2006

40

Structural Basis for Ca 2+ -mediated Interaction of the Perforin C2 Domain with Lipid Membranes

Yagi, Hiromasa, Conroy, Paul J., Leung, Eleanor W. W., Law, Ruby H. P., Trapani, Joseph A., Voskoboinik, Ilia, Whisstock, James C., Norton, Raymond S.

Journal:

Journal of Biological Chemistry

Year:

2015

File:

PDF, 9.70 MB

2015

41

Real-time visualization of perforin nanopore assembly

Leung, Carl, Hodel, Adrian W., Brennan, Amelia J., Lukoyanova, Natalya, Tran, Sharon, House, Colin M., Kondos, Stephanie C., Whisstock, James C., Dunstone, Michelle A., Trapani, Joseph A., Voskoboinik

Journal:

Nature Nanotechnology

Year:

2017

Language:

english

File:

PDF, 6.63 MB

english, 2017

42

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, Amelia J., Law, Ruby H. P., Conroy, Paul J., Noori, Tahereh, Lukoyanova, Natalya, Saibil, Helen, Yagita, Hideo, Ciccone, Annette, Verschoor, Sandra, Whisstock, James C., Trapani, Joseph A., V

Journal:

Cell Death & Differentiation

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

43

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2

Peter J.M. Steenbakkers, James A. Irving, Harry R. Harhangi, Willem J.C. Swinkels, Anna Akhmanova, Rembrandt Dijkerman, Mike S.M. Jetten, Chris van der Drift, James C. Whisstock, Huub J.M. Op den Camp

Journal:

Mycological Research

Year:

2008

Language:

english

File:

PDF, 428 KB

english, 2008

44

Hurpin Is a Selective Inhibitor of Lysosomal Cathepsin L and Protects Keratinocytes from Ultraviolet-Induced Apoptosis †

Welss, Thomas, Sun, Jiuru, Irving, James A., Blum, Rainer, Smith, A. Ian, Whisstock, James C., Pike, Robert N., von Mikecz, Anna, Ruzicka, Thomas, Bird, Phillip I., Abts, Harry F.

Journal:

Year:

2003

Language:

english

File:

PDF, 427 KB

english, 2003

45

Probing the Unfolding Pathway of 1-Antitrypsin

James, E. L., Whisstock, J. C., Gore, M. G., Bottomley, S. P.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 756 KB

english, 1999

46

Serpins Flex Their Muscle: I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS

Silverman, G. A., Whisstock, J. C., Bottomley, S. P., Huntington, J. A., Kaiserman, D., Luke, C. J., Pak, S. C., Reichhart, J.-M., Bird, P. I.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.85 MB

english, 2010

47

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Yang, Annie S.P., O’Neill, Matthew T., Jennison, Charlie, Lopaticki, Sash, Allison, Cody C., Armistead, Jennifer S., Erickson, Sara M., Rogers, Kelly L., Ellisdon, Andrew M., Whisstock, James C., Twee

Journal:

Year:

2017

Language:

english

File:

PDF, 3.41 MB

english, 2017

48

An Essential Role of Maspin in Embryogenesis and Tumor Suppression—Letter

Whisstock, James C., Bird, Phillip I.

Journal:

Cancer Research

Year:

2017

Language:

english

File:

PDF, 162 KB

english, 2017

49

Structural studies of plasmin inhibition

Wu, Guojie, Quek, Adam J., Caradoc-Davies, Tom T., Ekkel, Sue M., Mazzitelli, Blake, Whisstock, James C., Law, Ruby H.P.

Journal:

Biochemical Society Transactions

Year:

2019

File:

PDF, 4.48 MB

2019

50

Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

Murray‑Rust, Thomas A., Kerr, Felicity K., Thomas, Adele R., Wu, Tina, Yongqing, Tang, Ong, Poh Chee, Quinsey, Noelene S., Whisstock, James C., Wagenaar‑Bos, Ineke C., Freeman, Craig, Pike, Robert N.

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 537 KB

english, 2009

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